Startups, able to dream big and move fast, are uniquely positioned to turn sci-fi into reality. We need to reimagine how we power our world, build our cities, grow our food, and explore the cosmos. These are not pure software problems—breakthroughs in energy, materials, medicine are required, our understanding of life itself will dramatically change. We believe that small, agile teams armed with cutting-edge technology can tackle these fundamental challenges. From harnessing fusion power, to designing self-repairing infrastructure, creating abundant food in harsh climates, and extending human life spans — these audacious goals are within reach.